Is Mixing Cannabis (CBD) With Medications Safe?
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Is Mixing Cannabis (CBD) With Medications Safe?

In recent years, CBD has become one of the most famous wellness products in the market around the globe. However, most countries have not given a green flag to it as a medicinal and wellness supplement. Alongside this, the patients with routine medicines are always in confusion; it is always suggested that you must consult a doctor before doing some experiments with your medicines. Alongside this, there is a boom of mixing CBD with Alcohol and Nicotine – in certain cases and take experts’ advice. 

The mixing of CBD products with medications should be done with minimal THC%. Although CBD solely belongs to the medicinal family, it may not be enough for specific users to fight anxiety, insomnia, or glaucoma. A majority of the time, patients consult other pharmaceuticals to help with their medical conditions.

In most conditions, it is advised to speak with your doctor before mixing CBD with their prescribed medicines, as it is really unknown how CBD will react with a specific medicine. Sometimes the mixing combination can make prescribed pharmaceuticals less effective, more effective, or possibly even deadly.

To completely understand the concept, let’s explore a popular variety of common drugs that users may combine with CBD and its possible side effects when interacting with other drugs.


The information, including but not limited to text, graphics, images, and other material contained on this website are for informational purposes only. No material on this site is intended to substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Mixing CBD With Other Drugs 

  • CBD and Viagra

As per the Mayo Clinic, CBD can interact with various drugs, which also include Viagra, which is smoothly broken down by chemicals in the liver called cytochrome P450 enzymes. So, CBD may hinder other drugs’ breakdown, which can make Viagra less effective. In addition to this, the drug users who mix CBD with other drugs may also have increased levels of prescribed drugs in their system, leading to deadly adverse effects.

  • CBD and Rifampin
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Rifampin is the antibiotic medication used to treat Legionnaires’ and Tuberculosis disease; alongside this, it can also boost cytochrome P450 enzymes’ activity. According to the leading pharmaceutical newspaper, the mixing of CBD with Rifampin may boost THC’s breakdown and reduce the levels of the substance in the body.

  • CBD and Warfarin

Often prescribed treatment for blood clot prevention is Warfarin. It is a blood thinner, which should not be mixed with CBD. The major reason for avoiding the Warfarin’s mix with CBD is that CBD increases in easy bruising and nose bleeding as your blood becomes so thin. As per the Live Science, CBD affects the cytochrome P450 enzymes, which may inhibit the warfarin breakdown, leading to increased warfarin effects.

  • CBD and Benzodiazepines

Under any circumstances, any muscle relaxers drugs, including Benzodiazepines, which is not recommended to be mixed with CBD. Scientists have suggested that drug consumers who had experienced a higher likelihood of ‘central nervous system depression.’ It is extremely deadly as it often leads to heart-rate issues, breathing disorders, and users may also feel tired, drowsy, and ‘out of it.’ Due to this reason, users should never operate or drive heavy machinery if they mix CBD with Benzodiazepines.

  • CBD and Ketoconazole

The mix of CBD and Ketoconazole is considered as quite less hazardous than the other drugs earlier mentioned. However, this combination still has undesirable bodily effects. CBD restricts the Ketoconazole breakdown, which is an antifungal drug that effectively helps in stopping the infection. When combined with CBD with Ketoconazole, the user gets more THC in their body, leading to a stronger than expected high.

  • CBD and Prozac
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Prozac drugs work the same way as Ketoconazole. Prozac is an antidepressant fluoxetine drug. Users must talk with their physician or doctor on mental health awareness as it is on the rise. It is not yet proven, but researchers say that the mix of CBD with Prozac helps in boosting the

Serotonin, which ultimately helps consumers with their depression. This will sound like a solution for a few patients, but it is strictly recommended to contact your doctor before consuming the combination. 

  • CBD and Diabetes Medications

Several studies have suggested that regular CBD consumers have lower resistance to insulin effects as per the Mayo Clinic. Insulin is the hormone, which helps blood sugar to get inside cells. It also suggests that the CBD consumer’s body can better control blood sugar levels, effectively helping with diabetes. In contrast, some handful of studies also show that CBD users are more prone to developing prediabetes. A user who mixes CBD with diabetes medication should regularly and closely monitor their blood sugar levels.

  • Other Medications and Ingredients To Avoid with CBD

It is firmly advised that one must rely on the mentioned lists of drugs listed above. It is not a complete round-up of the medications that one should avoid while consuming CBD. It is advised to check the list of ingredients mentioned on the label of any drugs. Few ingredients to take into consideration is-

  • Beta-blockers
  • Propoxyphene
  • Levomethadyl Acetate
  • Buprenorphine
  • SNRIs
  • SSRIs
  • Sodium Oxybate
  • Antipsychotic medications

Positive Effects Of Mixing CBD With Other Drugs

When CBD is mixed with certain prescribed drugs, it can increase or decrease the drugs’ effects.

CBD interaction with neurotransmitter receptors in the central nervous system can effectively induce sedative effects on the user. THC’s sedative effects are directly linked with lethargy and drowsiness; CBD induces sedative effects, calming the body.

  • Interaction Between CBD and Chemotherapy Drugs

The chemotherapy treatment popularly used for cancer treatment is vital for taking a precise and accurate dosage. Chemotherapy drugs in an inadequate amount may result in ineffectiveness, and an excessive amount may result in over toxicity. If CBD is combined with chemotherapy treatment, it slows cancer growth and reduces cancer-related pain; the amount and type of cancer medication administered must account for the presence of CBD.

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Negative Effects Of Mixing CBD With Other Drugs

  • CBD Interaction with Drugs that Increase Risk of Bleeding

The drugs such as Warfarin or Ibuprofen used as a blood thinner or any drugs with the risk of blood-thinning when interacted with the CBD increases its effects. Using CBD with blood-thinning drugs effectively increases and prolongs drugs’ effects, increasing the risk of bleeding.

  • CBD Interaction with Anti-Seizure Medication

CBD is popularly known to be an effective epileptic seizures treatment, without any medical supervision. However, CBD can present certain problems under some circumstances with anti-seizure medication.

Bottom Line 

There are only a handful of studies held on the potential drug interaction 

between CBD and other drugs. So it isn’t straightforward to conclude. An overall minimum of 60% of the drugs on the market interacts with the CYP450 liver enzymes. When using CBD with other drugs, a large portion of the medication gets into your system due to CBD’s ability to block the enzymes. There is yet not a safe amount of drugs, so consult your physician before taking the combination. 

It is always best to speak with a doctor before mixing CBD with prescribed medicines as it is really unknown how CBD will react with a specific medicine. Sometimes the mixing combination can make prescribed pharmaceuticals less effective, more effective, or possibly even deadly.

Is Mixing Cannabis (CBD) With Medications Safe?

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