How Does CBD Interact with Medications?
- CBD, Health

How Does CBD Interact with Medications?

CBD oil in cancer treatment has a good safety profile, with few common side effects. Adverse side effects include nausea, fatigue, and changes in appetite and weight. Patients should consult a doctor if the side effects are persistent or bothersome.

CBD may counteract the effect of some medications, such as blood thinners and nonsteroidal anti-inflammatory drugs (NSAIDs). It can also interfere with drugs that depend on the body’s cannabinoid system, such as ibuprofen and prescription cannabinoids. For this reason, scientists recommend that people take a break of at least four hours when switching between CBD and these other drugs.

Medicines That Interact With CBD

A few medicines interact with CBD. They include cimetidine, rosiglitazone, and rifampin. We briefly discuss interactions with each of these medicines—more important information to be found in this article.

Cimetidine Interaction

Cimetidine is an OTC medicine for heartburn, acid reflux, and GERD. It works by reducing stomach acid. The drug is available as Tagamet® or Tagamet HB®.

Cimetidine increases CBD’s blood level by inhibiting P-glycoprotein pumps in the liver. P-glycoproteins are a class of proteins that remove foreign substances from the blood to prevent toxicity. Cimetidine also increases the amount of CBD that gets into the brain by blocking the uptake of CBD in the liver.

The effects of CBD are increased by cimetidine. Cimetidine may increase the risk of side effects such as fatigue, diarrhea, dizziness, and appetite loss. It may also increase the risk of other side effects such as sleepiness, nausea, vomiting, and anxiety. The risk of bleeding is also increased by cimetidine. If you take cimetidine along with CBD, do not stop taking your cimetidine without talking to your doctor first.

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Cimetidine should not be used with CBD if you:

Are on blood thinners, such as warfarin (Coumadin ® )

  • Have liver disease or cirrhosis
  • Are pregnant or breastfeeding

Rosiglitazone Interaction

Rosiglitazone is an oral diabetes medicine that increases insulin sensitivity. It is used to treat type 2 diabetes mellitus. It is available as Avandia® or Avandamet®.

Rosiglitazone increases CBD’s blood level by inhibiting P-glycoprotein pumps in the liver. P-glycoproteins are a class of proteins that remove foreign substances from the blood to prevent toxicity. Rosiglitazone also increases the amount of CBD that gets into the brain by blocking the uptake of CBD in the liver.

The effects of CBD are increased by rosiglitazone. Rosiglitazone may increase the risk of side effects such as fatigue, diarrhea, dizziness, and appetite loss. It may also increase the risk of other side effects such as sleepiness, nausea, vomiting, and anxiety. The risk of bleeding is also increased by rosiglitazone. If you take rosiglitazone along with CBD, do not stop taking your rosiglitazone without talking to your doctor first.

Rosiglitazone should not be used with CBD if you:

  • Have liver disease or cirrhosis
  • Are pregnant or breastfeeding

Rifampin Interaction

Rifampin is an antibiotic medicine used for tuberculosis (TB) and infections caused by bacteria resistant to other antibiotics. It works by killing bacteria that are sensitive to rifampin by damaging their DNA. The drug is available as Rifadin®, Rifamate®, Rimactane®, or Rifater®.

Rifampin increases CBD’s blood level by inhibiting P-glycoprotein pumps in the liver. P-glycoproteins are a class of proteins that remove foreign substances from the blood to prevent toxicity. Rifampin also increases the amount of CBD that gets into the brain by blocking the uptake of CBD in the liver.

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The effects of CBD are increased by rifampin. Rifampin may increase the risk of side effects such as fatigue, diarrhea, dizziness, and appetite loss. It may also increase the risk of other side effects such as sleepiness, nausea, vomiting, and anxiety. The risk of bleeding is also increased by rifampin. If you take rifampin along with CBD, do not stop taking your rifampin without talking to your doctor first.


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How Does CBD Interact with Medications?

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